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The circulatory and respiratory systems work together in a dynamic way to maintain oxygen and carbon dioxide levels in the human body. Students will engage with content through the New York State Making Connections Lab. In terms of the marathon runner mystery/problem, students may think that the runner died because of a heart attack or overexertion in some way. This instruction should help them see why the evidence doesn't support that conclusion.

In this 5E sequence, students learn that diabetes is a failure of homeostasis and explore the multiple causes behind the rise in type II diabetes and how some diseases (e.g. diabetes, cancer) have a complex epidemiology.

The incidence of disease at different point in history, and in different communities, is affected by lifestyle, access to healthy infrastructure, emerging pathogens, and new treatments. In this unit students will explore both the disappearance of certain diseases thanks to antibiotics and vaccines (strep and polio for example), and the emergence or growth of other diseases (such as asthma and diabetes). As a part of this unit, students may review cellular processes such as cell division. Accessing data from maps, graphs, and other non-print texts and using that data to draw conclusions and ask further questions is a key component to this unit.

One example of homeostasis in humans is thermoregulation?the maintenance of core body temperature within a narrow range. Many mechanisms exist in the human body to make it possible for temperature to stay within a narrow range, close to 98.6oF; very high and very low temperatures indicate a disruption in homeostasis.

In this performance task, students apply their knowledge of the different ways that the body maintains homeostasis, in order to determine the cause for a marathon runner's collapse.

The rise and near eradication of Polio provides an interesting lens through which to explore viral disease, the immune response, and the process of vaccination. In this 5E sequence, students use animations, diagrams, and graphs to explore the characteristics of viral infection and how the immune system responds. In comparing Polio and influenza, students have an opportunity to discuss different types of viruses and to dive deeper into antigen/antibody specificity.